Genetic risk variants for these disorders are proposed to lie along a spectrum of effect sizes: from rare monogenic variants of large effect, to common but relatively weak variants that, in aggregate, result in disorder. Although the aetiologies of these disorders are incompletely understood, they are known to be highly heritable with complex genetic architectures. Together with major depressive disorder (MDD) they are amongst the top ten leading causes of disability worldwide. Schizophrenia (SZ) and bipolar disorder (BD) are severe neurodevelopmental disorders with a combined lifetime prevalence of around 2%. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products to declare.
Thorsten Feiweier from Siemens Healthcare for providing the prototype diffusion sequence used in this study. Scottish Enterprise and Pfizer Inc., provided funding towards this study. The specific roles of these authors are articulated in the author contributions section.Ĭompeting interests: ZAH, NJB, JD and BW are/were employees of Pfizer Inc. Pfizer Inc., provided support in the form of salaries for authors ZAH, NJB, JD and BW but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. HCW is supported by a College Fellowship from the University of Edinburgh and a JMAS SIM fellowship from the Royal College of Physicians of Edinburgh. The investigators also acknowledge the financial support of National Health Service (NHS) Research Scotland, through the Scottish Mental Health Research Network ( ) who provided assistance with subject recruitment and cognitive assessments. Imaging aspects also received financial support from the Dr Mortimer and Theresa Sackler Foundation. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was supported by an award from the Translational Medicine Research Collaboration-a consortium made up of the Universities of Aberdeen, Dundee, Edinburgh and Glasgow, the four associated NHS Health Boards (Grampian, Tayside, Lothian and Greater Glasgow & Clyde), Scottish Enterprise and Pfizer. Received: MaAccepted: Published: June 23, 2015Ĭopyright: © 2015 Whalley et al. PLoS ONE 10(6):Įditor: Therese van Amelsvoort, Maastricht University, NETHERLANDS
(2015) Effects of a Balanced Translocation between Chromosomes 1 and 11 Disrupting the DISC1 Locus on White Matter Integrity. Citation: Whalley HC, Dimitrova R, Sprooten E, Dauvermann MR, Romaniuk L, Duff B, et al.
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